Adult trkB Signaling in Parvalbumin Interneurons is Essential to Prefrontal Network Dynamics

Inhibitory interneurons expressing parvalbumin (PV) are central to cortical network dynamics, generation of γ oscillations, and cognition. Dysfunction PV disrupts information processing cognitive behavior. Brain-derived neurotrophic factor (BDNF)/tyrosine receptor kinase B (trkB) signaling regulates the maturation but is also implicated in their adult multidimensional functions. Using a novel viral strategy for cell-type-specific spatially restricted expression dominant-negative trkB (trkB.DN), we show that BDNF/trkB essential integrity maintenance prefrontal male female mice. Reduced medial cortex (mPFC) resulted deficient inhibition increased baseline local field potential (LFP) activity broad frequency band. The altered was particularly pronounced during activation associated with changed dynamics excitatory neurons, as well decreased modulation LFP, abnormalities appeared generalize across stimuli brain states. In addition, our findings link reduced aggression. Together investigations demonstrate mPFC Our data provide direct support suggested association between signaling, inhibition, circuitry. SIGNIFICANCE STATEMENT promotes inhibitory interneurons, neurons rhythms, Here, used approach establish role activities. caused morphologic alterations, dynamics. manifest states aberrant activities results circuit function directly links brain.